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Objectives: To investigate whether the -3826 A-G point mutation of the uncoupling protein 1 (UCP1) gene and the Trp64Arg mutation of the sz3-adrenergic receptor (sz3-AR) gene are associated with increased susceptibility to weight gain and hyperlipidemia in postmenopausal women. Methods: We genotyped 312 Japanese women for UCP1 and sz3-AR gene polymorphisms, and investigated their effects on anthropometrical...
Objective: It is conceivable that, since menopause accelerates the continuous bone loss determined by age, a specific configuration of bone mass determinants during the first postmenopausal years occurs. Methods: To establish their value as indicators of bone mass in women with recent natural menopause, we assessed relationships between bone mineral density (BMD) and age, menopausal age, body mass...
Background: Different hormonal replacement regimens are used for treating climacteric complaints; however, not all of them have the same clinical profile. Cardiovascular disease (CVD) is a major health problem and tibolone, raloxifene, estradiol (alone or with cyproterone acetate) have been added to cholesterol-fed rabbits to study atherosclerosis. Methods: A total of 48 cholesterol-fed New Zealand...
Objectives: This paper examines the evidence supporting testosterone replacement in aging males. Confounding factors contributing to low testosterone levels and challenges to diagnosis of the andropause will also be considered. Methods: A thorough review using an integrative approach citing published literature and the ongoing work of the authors. A search was performed using National Library of Medicine...
Objectives: To review the morphological and molecular events responsible for uterine bleeding in health and disease. Methods: Review of pertinent literature focusing on the histology and pathophysiology of normal and abnormal uterine bleeding (AUB). Results: The seat of normal menstrual bleeding is located in the upper two-thirds of the endometrial mucosa and is recognized by tissue necrosis, disruption...
Objective: To objectively analyze vaginal dryness in postmenopausal women. Methods: Forty healthy postmenopausal women, were divided in three groups according to the treatment they received. Group I, conjugated equine estrogens (CEE) 0.625 mg/day (n=20), group II, CEE 0.625 mg/day plus chlormadinone 1 mg/day (n=13), and group III, CEE 0.625 mg/day plus medroxyprogesterone 2.5 mg/day (n=7). Vaginal...
Objectives: To determine whether improvement in endothelial function of the brachial artery observed in women treated with hormone replacement therapy (HRT) may be explained by changes in lipid profile or blood pressure, information was used obtained in a single-centre, randomised, double blind, placebo-controlled trial. Methods: Hundred-and-five healthy postmenopausal women, aged 50-65 years, were...
Due to the younger age and the ever wider use of adjuvant chemotherapy and antiestrogens, menopausal symptoms are a frequent cause of concern for breast cancer patients. Objectives: To determine the prevalence of menopausal symptoms, and to explore the attitudes toward Hormone Replacement Therapy (HRT) or other treatments and the willingness to take oestrogen in breast cancer patients. Methods: A...
Objectives: The purpose of this study was to assess sociodemographic and behavioral factors in relation to menopausal status in a representative sample of the United States population. Methods: Data were taken from the 1999 National Health Interview Survey (NHIS), limited to women aged 40-54 years who had not undergone surgical menopause. Menopausal transition was defined as absence of menstrual cycles...
Objectives: To evaluate the effect of three distinct hormone replacement therapy regimens on mammography. Methods: 121 postmenopausal women who had never received or were past users of hormone replacement therapy were studied prospectively. Women with an intact uterus were randomly allocated either to conjugated equine estrogens 0.625 mg plus medroxyprogesterone acetate 5 mg (CEE/MPA, n=34) or to...
Objective: The purpose of this study was to determine the sources of information and hormone replacement therapy (HRT) prescribing practices of gynecologists in the capital city of Puebla, Mexico. Methods: Practicing gynecologists (n=44) in 29 colonias (neighborhoods) in the city of Puebla completed a self-administered standardized questionnaire. Survey topics included primary sources of information...
Objectives: To evaluate the use of hormone replacement therapy (HRT), the prevalence of climacteric symptoms, and the knowledge about HRT. Methods: A prospective study was conducted by telephone interview among a randomly selected population-based sample of 978 Hong Kong Chinese women aged 40-60 years. Results: Of 414 women with a history of either natural or surgical menopause, 22 (5.3%) and 17 (4...
Background: Some extragenital symptoms have been suggested to be associated with the menopause and thus to be affected by estrogen status. In such case extragenital symptoms may be more frequent in postmenopausal women without hormone replacement therapy (HRT) than in premenopausal women or women using HRT. Objective: To assess if the prevalence of a number of extragenital symptoms is higher in postmenopausal...
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